RNA-binding proteins (RBPs) are essential factors required for the physiological function of
neurons, muscle, and other tissue types. In keeping with this, a growing body of genetic …

RNA-binding protein (RBP) dysfunction is a fundamental hallmark of amyotrophic lateral
sclerosis (ALS) and related neuromuscular disorders. Abnormal neuronal excitability is also …

Background Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative
disease characterized by progressive loss of upper and lower motor neurons. While …

Matrin‐3 (MATR3) is an RNA‐binding protein implicated in neurodegenerative and
neurodevelopmental diseases. However, little is known regarding the role of MATR3 in …

To understand how mutations in Matrin 3 (MATR3) cause amyotrophic lateral sclerosis
(ALS) and distal myopathy, we used transcriptome and interactome analysis, coupled with …

Mutations in the MATR3 gene encoding the nucleotide binding protein Matrin 3 have
recently been identified as causing a subset of familial amyotrophic lateral sclerosis (fALS) …

Abnormalities in nucleic acid processing are associated with the development of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in Matrin …

A number of neuromuscular and muscular diseases, including amyotrophic lateral sclerosis
(ALS), spinal muscular atrophy (SMA) and several myopathies, are associated to mutations …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder
characterized by an extensive loss of motor neurons in the primary motor cortex, brainstem …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of both upper and lower motor neurons in the brain and spinal cord. ALS is …