The nucleosome is the universal protein/DNA element repeated throughout the chromatin of
eukaryotic cells (Kornberg 1977; McGhee and Felsenfeld 1980). Presumably as a …

The nucleosome is the elementary DNA-protein unit responsible for the organization of
chromatin (for review, see Kornberg 1977; McGhee and Felsenfeld 1980). Investigations in …

The crystal structure of the histone octamer has now been determined at 3· 1 Å resolution
and refined to a crystallographic R value of 25· 5%. The overall shape of the structure is …

The crystal structure of the nucleosome core particle has been studied by neutron diffraction
to a resolution of 16 Å. By using H 2 OD 2 O solvent contrast variation, the structures of the …

Crystals have been grown of intact (unproteolysed) nucleosome cores from a variety of
sources. The unit cells are all very similar, with one core particle per asymmetric unit. The X …

The DNA in the nucleosome falls into two topologically distinct classes (Noll 1976c). The
DNA of the first class consists of 140 base pairs that are more tightly associated with the …

A high-resolution map for the arrangement of histones along DNA in the nucleosome core
particles has been determined by a new sequencing procedure. The lysine groups of …

Isolated HeLa cell nucleosomes (core particles) were labeled at the 5'-termini of their DNA
with 32P using [gamma-32P] ATP and polynucleotide kne by sequential methylation …

Revised Manuscript Received October 12, 1987 abstract: The conformation of the histone
octamer complex in solution has been shown, by circular dichroism studies, to be highly …

Revised Manuscript Received June 10, 1991 abstract: We have examined the structures of
unique sequence, A/T-rich DNAs that are predicted to be relatively rigid [oligo (dA)* oligo …