Background The ACCOMPLISH (Avoiding Cardiovascular Events Through Combination
Therapy in Patients Living with Systolic Hypertension) trial demonstrated that combination …

Background The optimal combination drug therapy for hypertension is not established,
although current US guidelines recommend inclusion of a diuretic. We hypothesized that …

ACCOMPLISH is the first trial designed to compare the effects on major fatal and non‐fatal
cardiovascular endpoints of two forms of antihypertensive combination therapy: benazepril …

Although multidrug therapy is required in order to achieve good blood pressure control in
many hypertensives, there are no studies directly comparing fixed-dose combinations as …

Context Antihypertensive therapy is well established to reduce hypertension-related
morbidity and mortality, but the optimal first-step therapy is unknown. Objective To determine …

The Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT)
provides a unique opportunity to compare the long-term relative safety and efficacy of …

Reducing blood pressure (BP) to target levels is a major priority in preventing clinical events
in hypertension. Typically this requires more than one drug, and recent guidelines on …

Background: There is controversy regarding the impact that different antihypertensive
regimens, including modern combination therapy, have on the incidence of myocardial …

Prevent Heart Attack Trial (ALLHAT) Antihypertensive and Lipid-Lowering Treatment to
Inhibitor or Calcium Channel Blocker vs Diu Page 1 current as of August 3, 2009. Online …

Objectives Current guidelines recommend the use of multiple medications for hypertension.
The present study was aimed at determining which combination was optimal to prevent …