Hydrogen bonding in DNA—a return to the status quo Page 1 Me F F N N Me O O H Me Me F
F Me 1 2 3 4 5 O HO HO Me F F O HO HO N N Me O O H (a) (b) Hydrogen bonding in DNA—a …

Recent experiments have presented evidence that Watson–Crick hydrogen bonds in a base
pair are not absolute requirements for efficient synthesis of that pair by DNA polymerase …

That hydrogen bonds play a central role in forming Watson–Crick (W–C) AT and GC base
pairs is a fundamental paradigm dating from the discovery of the structure of DNA in 1953. In …

Up till now, there has been a significant disagreement between theory and experiment
regarding hydrogen bond lengths in Watson− Crick base pairs. To investigate the possible …

We report the properties of hydrophobic isosteres of pyrimidines and purines in synthetic
DNA duplexes. Phenyl nucleosides 1 and 2 are nonpolar isosteres of the natural thymidine …

The physical and chemical factors that allow DNA to perform its functions in the cell have
been studied for several decades. Recent advances in the synthesis and manipulation of …

Based on a series of elegant experiments, Kool and coworkers [1] concluded that not
Watson±Crick hydrogen bonding but steric effects, that is, the shape of DNA bases is mainly …

Studies of the enzymatic mechanisms responsible for DNA synthesis and mutations have
often focused on the structural and energetic issues of base pair geometry and Watson …

▪ Abstract Understanding the mechanisms by which genetic information is replicated is
important both to basic knowledge of biological organisms and to many useful applications …

As part of an effort to expand the genetic alphabet, we examined the synthesis of DNA with
six different unnatural nucleotides bearing methoxy-derivatized nucleobase analogues …