FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant …
LM Kelly, Q Liu, JL Kutok, IR Williams… - Blood, The Journal …, 2002 - ashpublications.org
FLT3 receptor tyrosine kinase is expressed on lymphoid and myeloid progenitors in the
hematopoietic system. Activating mutations in FLT3 have been identified in approximately …
hematopoietic system. Activating mutations in FLT3 have been identified in approximately …
FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model
BH Lee, IR Williams, E Anastasiadou, CL Boulton… - Oncogene, 2005 - nature.com
Activating FMS-like tyrosine kinase 3 (FLT3) mutations have been identified in∼ 30% of
patients with acute myelogenous leukemia (AML), and recently in a smaller subset of …
patients with acute myelogenous leukemia (AML), and recently in a smaller subset of …
Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model
L Li, O Piloto, HB Nguyen, K Greenberg… - Blood, The Journal …, 2008 - ashpublications.org
Constitutive activation of FMS-like tyrosine kinase 3 (FLT3) by internal tandem duplication
(ITD) mutations is one of the most common molecular alterations known in acute myeloid …
(ITD) mutations is one of the most common molecular alterations known in acute myeloid …
FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model
R Grundler, C Miething, C Thiede, C Peschel, J Duyster - Blood, 2005 - ashpublications.org
Activating mutations of the Fms-like tyrosine kinase 3 (FLT3) receptor are the most common
genetic alteration in acute myeloid leukemia (AML). Two distinct groups of FLT3 mutations …
genetic alteration in acute myeloid leukemia (AML). Two distinct groups of FLT3 mutations …
A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations
Internal tandem duplication (ITD) mutations of the receptor tyrosine kinase FLT3 have been
found in 20% to 30% of patients with acute myeloid leukemia (AML). These mutations …
found in 20% to 30% of patients with acute myeloid leukemia (AML). These mutations …
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
M Mizuki, R Fenski, H Halfter… - Blood, The Journal …, 2000 - ashpublications.org
Somatic mutations of the receptor tyrosine kinase Flt3 consisting of internal tandem
duplications (ITD) occur in 20% of patients with acute myeloid leukemia. They are …
duplications (ITD) occur in 20% of patients with acute myeloid leukemia. They are …
Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor
F Breitenbuecher, S Schnittger… - Blood, The Journal …, 2009 - ashpublications.org
In acute myeloid leukemia (AML), internal tandem duplications (ITDs) of the juxtamembrane
(JM) of FLT3 have been shown to play a crucial role in driving proliferation and survival of …
(JM) of FLT3 have been shown to play a crucial role in driving proliferation and survival of …
Detection of FLT3 internal tandem duplication and D835 mutations by a multiplex polymerase chain reaction and capillary electrophoresis assay
FLT3 is a receptor tyrosine kinase that is expressed on early hematopoietic progenitor cells
and plays an important role in stem cell survival and differentiation. Two different types of …
and plays an important role in stem cell survival and differentiation. Two different types of …
The roles of FLT3 in hematopoiesis and leukemia
DG Gilliland, JD Griffin - Blood, The Journal of the American …, 2002 - ashpublications.org
FLT3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is
important for the normal development of stem cells and the immune system. The ligand for …
important for the normal development of stem cells and the immune system. The ligand for …
The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated …
K Spiekermann, RJ Dirschinger… - Blood, The Journal …, 2003 - ashpublications.org
Activating mutations of the protein tyrosine kinase (PTK) FLT3 can be found in approximately
30% of patients with acute myeloid leukemia (AML), thereby representing the most frequent …
30% of patients with acute myeloid leukemia (AML), thereby representing the most frequent …