Long-standing beliefs have associated aging in men with declines in sexual performance,
sex steroid serum levels, and fertility. Critical analysis of recent data, however, indicates that …

Aging of humans is associated with functional alterations at all levels of the reproductive axis
and affects both steroidogenic and spermatogenic compartments. Unlike female …

Aging in men is associated with modest changes of the secretory and regulatory functions of
the hypothalamic-pituitary-testicular axis. Similarly, some age-related changes in …

Context: It is unclear whether declining sexual function in older men is a cause or
consequence of reduced androgen status. Objective: Longitudinal associations were …

A wide variety of disorders, medications, physical factors, and trauma can alter testicular
function and reproductive function in men as they age. There are no precise age limits for …

For centuries, the importance of the testes for the maintenance of male phenotype,
psychosexual behavior, and physical power has been recognized. Indeed, testicular extracts …

A cross-sectional study on 220 men, aged 41–93 yr, was conducted to determine whether
age-related changes in circulating pituitary and gonadal hormone levels are related to …

No discrete event marks a transition to male reproductive senescence; however, a number
of investigations have suggested that male fertility and reproductive hormone secretion …

In male mammals, changes at all levels of the hypothalamic-pituitary-testicular axis,
including alterations in the GnRH pulse generator, gonadotropin secretion, and testicular …

Aging in healthy men is accompanied by a progressive decline of gonadal function with, in
particular, a decline of Leydig cell function and decreased testosterone production …