Bioinformatics tools are employed lately for in silico structure-function analysis of proteins.
HIV protease inhibitors nelfinavir and tipranavir belong to the extended multi-ring systems …

Therapeutic pressure by protease inhibitors (PIs) contributes to accumulation of mutations in
the HIV type 1 (HIV-1) protease (PR) leading to development of drug resistance with …

Nelfinavir (Viracept®) is a potent, non-peptidic inhibitor of HIV-1 Protease, which has been
marketed for the treatment of HIV infected patients. However, HIV-1 develops drug …

Starting three decades ago and spreading rapidly around the world, acquired
immunodeficiency syndrome (AIDS) is an infectious disease distinct from other contagious …

Mutations that arise in HIV-1 protease after exposure to various HIV-1 protease inhibitors
have proved to be a difficult aspect in the treatment of HIV. Mutations in the binding pocket of …

We have investigated and highlighted the behavior of binding residue, Asp25 by
computational analysis, which play an important role in understanding docking process with …

The intense research on small molecule inhibitors of Human immunodeficiency virus (HIV)-
protease (PR) has produced a diverse class of chemical scaffolds which includes clinically …

Efforts to develop therapeutically relevant HIV protease inhibitors as medicinal agents in
confronting the AIDS crisis have been aided by the wealth of fundamental information …

Structure-based drug design by use of structural biology remains one of the most logical and
aesthetically pleasing approaches in drug discover paradigms. Managing AIDS, is the most …

Protease inhibitors (PIs) are crucial drugs in highly active antiretroviral therapy for human
immunodeficiency virus‐1 (HIV‐1) infections. However, resistance owing to mutations …