Background: Increased concentrations of plasma total homocysteine (tHcy) have been
associated with age-related diseases, including dementia, stroke, and Parkinson disease …

Background: Increased plasma total homocysteine (tHcy) is a risk factor for neurological
diseases, but the underlying pathophysiology has not been adequately explained. Methods …

Background An elevated plasma homocysteine (Hcy) level has been prospectively
associated with an increased risk of vascular and degenerative dementias. An Hcy elevation …

Homocysteine is formed by demethylation of methionine and is involved in transmethylation
mechanisms. Hyperhomocysteinemia is associated with a wide range of clinical …

Abstract Background/Aims: Increasing evidence suggests that elevated levels of
homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of …

Background: Elevated plasma total homocysteine (tHcy) is a risk factor for cardiovascular
disease and is reported to be an independent risk factor for Alzheimer disease (AD) and …

Diseases of the central nervous system are found in patients with severe
hyperhomocysteinemia (HHcy). Epidemiological studies show a positive, dose-dependent …

Disturbed homocysteine metabolism is a risk factor for Alzheimer's disease (AD) and may
contribute to the disease pathophysiology by increasing both amyloid-β (Aβ) production and …

Cognitive dysfunction and dementia are common non-motor symptoms of PD. hcy has
various neuronal and endothelial cellular toxicities. The clinical relevance of the levodopa …

Background It has been reported that plasma tHcy concentration is elevated in patients with
Alzheimer's disease (AD) and relates to the progress or the development of AD. In the …