Both intact and nuclease-isolated chromatin fibers have been examined at different degrees
of salt-induced compaction, using a variety of preparation techniques. The results suggest …

The basic chromatin fibre (the 10 nm diameter fibre) is a linear repeating array of
nucleosomes, or nucleosome filament. The core of each disk-like nucleosome is a wedge …

The last years have witnessed rapid progress in our understanding of chromatin structure at
the nucleosome or beads-on-a-string level (Elgin and Weintraub 1975; Kornberg 1977) …

The question as to how the strands of chromatin are packed into the eukaryotic nucleus has
intrigued biologists and biochemists for many years. Although there is ample space in the …

We describe the results of a systematic study, using electron microscopy, of the effects of
ionic strength on the morphology of chromatin and of H1-depleted chromatin. With …

Unique roles have been identified for the histone octamer in the formation and stabilization
of higher order chromatin structures. Histone octamers were assembled onto 12 tandem …

Chromatin prepared by brief digestion of nuclei with micrococcal nuclease, and extracted in
0.2 mM EDTA, appears in the electron microscope as filaments of about 100 A diameter …

The" 30-nm" chromatin fibers, as observed in eukaryotic nuclei, are considered a discrete
level in a hierarchy of DNA folding. At present, there is considerable debate as to how the …

The three dimensional (3D) structure of chromatin fibers in sections of nuclei has been
determined using electron tomography. Low temperature embedding and nucleic acid …

There is considerable current interest in the organisation of nucleosomes in chromatin. A
strong X-ray and neutron semi-meridional diffraction peak at approximately 10 nm had …