TAD disruption as oncogenic driver
Topologically Associating Domains (TADs) are conserved during evolution and play roles in
guiding and constraining long-range regulation of gene expression. Disruption of TAD …
guiding and constraining long-range regulation of gene expression. Disruption of TAD …
Breaking TADs: how alterations of chromatin domains result in disease
Spatial organization is an inherent property of the vertebrate genome to accommodate the
roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically …
roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically …
Evolutionary stability of topologically associating domains is associated with conserved gene regulation
J Krefting, MA Andrade-Navarro, J Ibn-Salem - BMC biology, 2018 - Springer
Background The human genome is highly organized in the three-dimensional nucleus.
Chromosomes fold locally into topologically associating domains (TADs) defined by …
Chromosomes fold locally into topologically associating domains (TADs) defined by …
[HTML][HTML] Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions
Mammalian genomes are organized into megabase-scale topologically associated domains
(TADs). We demonstrate that disruption of TADs can rewire long-range regulatory …
(TADs). We demonstrate that disruption of TADs can rewire long-range regulatory …
Three-dimensional chromatin in disease: what holds us together and what drives us apart?
DM Ibrahim, S Mundlos - Current Opinion in Cell Biology, 2020 - Elsevier
Recent advances in understanding spatial genome organization inside the nucleus have
shown that chromatin is compartmentalized into megabase-scale units known as …
shown that chromatin is compartmentalized into megabase-scale units known as …
[HTML][HTML] When TADs go bad: chromatin structure and nuclear organisation in human disease
Chromatin in the interphase nucleus is organised as a hierarchical series of structural
domains, including self-interacting domains called topologically associating domains …
domains, including self-interacting domains called topologically associating domains …
Defining functionally relevant spatial chromatin domains: it is a TAD complicated
N Sikorska, T Sexton - Journal of molecular biology, 2020 - Elsevier
Chromosome conformation capture and orthologous methods uncovered the spatial
organization of metazoan chromosomes into autonomously folded substructures, often …
organization of metazoan chromosomes into autonomously folded substructures, often …
Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation
The human genome is segmented into topologically associating domains (TADs), but the
role of this conserved organization during transient changes in gene expression is not …
role of this conserved organization during transient changes in gene expression is not …
TADs: Dynamic structures to create stable regulatory functions
JA da Costa-Nunes, D Noordermeer - Current Opinion in Structural Biology, 2023 - Elsevier
Mammalian chromosomes are organized at different length scales within the cell nucleus.
Topologically Associating Domains (TADs) are structural units of 3D genome organization …
Topologically Associating Domains (TADs) are structural units of 3D genome organization …
To loop or not to loop: what is the role of TADs in enhancer function and gene regulation?
GR Cavalheiro, T Pollex, EEM Furlong - Current Opinion in Genetics & …, 2021 - Elsevier
The past decade has seen a huge jump in the resolution and scale at which we can
interrogate the three-dimensional properties of the genome. This revealed different types of …
interrogate the three-dimensional properties of the genome. This revealed different types of …