Age and sex influence serum cholesterol levels, but the underlying mechanisms remain
unclear. To investigate further, we measured cholesterol, precursors (surrogate synthesis …

In aging liver oxidative stress increases due to the decrease in antioxidant bio-molecules
such as estrogens which can be modified by hormonal replacement therapy (HRT). With this …

Abstract In Sprague-Dawley rats at the ages of 5 weeks (young) and 9 months (adult), the
activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in age-matched …

Background and purpose: The specific molecular mediators involved in dyslipidemia in
older people are not yet clearly understood. The current study was, thus, an attempt to …

Aging is a major risk factor for many chronic diseases due to increased vulnerability to
external stress and susceptibility to disease. Aging is associated with metabolic liver disease …

Purpose. Aged male rats show a decrease in liver PPARα. We aimed to determine if the
sexual dimorphism in lipid metabolism observed in the PPARα−/− mouse is also present in …

Abstract Expression profiles of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR),
apolipoprotein E (ApoE) and cholesterol 24S-hydroxylase (CYP46), proteins involved in …

Aging could be due to the accumulation of oxidative damage. On the other hand, growth
hormone (GH) and estrogen deficiency induce deleterious effects on different tissues, and …

OBJECTIVE: To investigate the protective effect of 17β-estradiol (E2), peganum harmala
extract (PHE) administration and calorie restriction (CR) treatment (60%) on oxidative stress …

Background Estrogens regulate sexual function and also have a significant role in various
pathophysiological processes. Estrogens have a non-reproductive role as the modulators of …