The effects of alone and combination tamoxifen, raloxifene and estrogen on lipid profile and atherogenic index of ovariectomized type 2 diabetic rats

MN Ebrahimi, M Khaksari, G Sepehri, GA Karam… - Life Sciences, 2020 - Elsevier
Introduction The cardiovascular dysfunctions in postmenopausal diabetic women increase
relative to premenopausal women. In this study we evaluated protective effects of selective …

Therapeutic effects of tamoxifen on metabolic parameters and cytokines modulation in rat model of postmenopausal diabetic cardiovascular dysfunction: Role of …

H Azizian, M Khaksari, G Asadikaram, G Sepehri… - International …, 2018 - Elsevier
In postmenopausal women, the risk of diabetic cardiovascular disease drastically increases
compared with that of premenopausal women. In the present study we surveyed the effects …

Protective effects of combining SERMs with estrogen on metabolic parameters in postmenopausal diabetic cardiovascular dysfunction: The role of cytokines and …

M Khaksari, A Raji-Amirhasani, H Bashiri, MN Ebrahimi… - Steroids, 2022 - Elsevier
Introduction The beneficial effects of the administration of selective estrogen receptor
modulators (SERMs) and estrogen (E2), alone or in combination with each other, have been …

Selective estrogen receptor α and β antagonist aggravate cardiovascular dysfunction in type 2 diabetic ovariectomized female rats

H Azizian, Z Farhadi, M Khaksari - Hormone Molecular Biology and …, 2022 - degruyter.com
Abstract Objectives Type 2 diabetes (T2D) is a major risk factor for cardiovascular disorders
(CVD), characterized by pathological diastolic as well as systolic dysfunction, ventricular …

Distinct role of estrogen receptor-alpha and beta on postmenopausal diabetes-induced vascular dysfunction

S Bansal, K Chopra - General and Comparative Endocrinology, 2014 - Elsevier
Estrogen is known to influence vascular functions and insulin sensitivity, but the relative
contribution of estrogen receptor (ER) isoforms in postmenopausal diabetes-induced …

Selective ER-α agonist alleviates vascular endothelial dysfunction in ovariectomized type 2 diabetic rats

S Bansal, K Chopra - Molecular and cellular endocrinology, 2018 - Elsevier
Postmenopausal diabetic women represent a specific risk group with a greater incidence of
vascular deficits as compared with age-matched men or non-diabetic women. 17β-estradiol …

[HTML][HTML] Progesterone eliminates 17β-estradiol-Mediated cardioprotection against diabetic cardiovascular dysfunction in ovariectomized rats

H Azizian, M Khaksari, G Asadikaram, M Esmailidehaj… - biomedical …, 2021 - Elsevier
Abstract Background Type2 Diabetes (T2D) remains one of the most important causes of
cardiovascular diseases (CVD). Menopause leads to an increase in CVD and metabolic …

Substitution of calorie restriction for protective effects of estrogen on cardiometabolic risk factors and oxidative stress in obese postmenopausal rat model

Z Hajializadeh, M Khaksari, H Najafipour, M Sanjari… - Life Sciences, 2022 - Elsevier
Estrogen has an anti-obesity effect and plays an important role in improving cardiometabolic
disorders. Weight loss and reduction in calorie intake impede the development of obesity …

Effect of soybean oil on atherogenic metabolic risks associated with estrogen deficiency in ovariectomized rats: dietary soybean oil modulate atherogenic risks in …

HA Hassan, MA Abdel-Wahhab - Journal of physiology and biochemistry, 2012 - Springer
The aim of the present study was to investigate the cardiac biomarker changes in
experimental bilateral ovariectomized (OVX) rats in addition to evaluating the role of …

A novel concept to preserve the beneficial effects of hormone replacement therapy in bilaterally female ovariectomized rats: role of lovastatin therapy

SE El-Swefy, ME Asker, SI Ali, HE Mohammed - Pharmacological research, 2002 - Elsevier
Estrogen replacement therapy (ERT) is claimed to reduce cardiovascular mortality by about
50% in postmenopausal women. This improvement is caused by favorable changes in lipid …