Macrophage tolerance: CD47–SIRP-α–mediated signals matter | Nature Immunology Skip to
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Mice devoid of T, B, and natural killer (NK) cells distinguish between self and allogeneic
nonself despite the absence of an adaptive immune system. When challenged with an …

Graft failure in the transplantation of hematopoietic stem cells occurs despite donor-host
genetic identity of human leukocyte antigens, suggesting that additional factors modulate …

Signal regulatory protein α (SIRPα) is a critical immune inhibitory receptor on macrophages,
and its interaction with CD47, a ligand for SIRPα, prevents autologous phagocytosis. We …

It has been shown that in xenotransplantation of human cells into immunodeficient mice, the
mouse strain background is critical. For example, the nonobese diabetic (NOD) strain is …

In human-to-mouse xenogeneic transplantation, polymorphisms of signal-regulatory protein
α (SIRPA) that decide their binding affinity for human CD47 are critical for engraftment …

We have previously proven that human macrophages can phagocytose porcine cells even
in the absence of Ab or complement opsonization, indicating that macrophages present a …

A numerous number of positive and negative signals via various molecules modulate T-cell
activation. Within the various transmembrane proteins, SIRPγ is of interest since it is not …

Signal-regulatory proteins (SIRPs) represent a new family of inhibitory/activating receptor
pairs. They consist of 3 highly homologous immunoglobulin (Ig)–like domains in their …

Phagocytes engulf foreign cells but not 'self'in part because self cells express CD47 as a
ligand for signal regulatory protein SIRPα, which inhibits phagocytosis. Motivated by reports …