Intestinal tissue-resident memory CD8 T cells (Trm) are non-recirculating effector cells
ideally positioned to detect and react to microbial infections in the gut mucosa. There is an …

T cells differentiate into highly diverse subsets and display plasticity depending on the
environment. Although lymphocytes are key mediators of inflammation, functional …

Inflammatory bowel diseases are associated with dysregulated immune responses in the
intestinal tissue. Four molecularly identified macrophage subsets control immune …

Resident memory CD8 T (Trm) cells have been shown to provide effective protective
responses in the small intestine (SI) in mice. A better understanding of the generation and …

Crohn's disease (CD) is a chronic transmural inflammation of intestinal segments caused by
dysregulated interaction between microbiome and gut immune system. Here, we profile, via …

Therapeutic blockade of co-inhibitory immune receptors PD-1 and CTLA-4 has
revolutionized oncology, but treatments are limited by immune-related adverse events …

Lympho-epithelial interactions between intestinal T resident memory cells (Trm) and the
epithelium have been associated with inflammatory bowel disease (IBD) activity. We …

Tissue‐resident memory T cells (TRMs) are plentiful in the memory T cell pool and persist in
barrier sites without recirculating. Increasing evidence has shown that some kinds of CD8+ …

CD4+ T helper (Th) cells that express the gut homing chemokine receptor CCR9 are
increased in the peripheral blood of patients with inflammatory bowel disease and Sjögren's …

Tissue-resident memory T (TRM) cells remain poised in the tissue and mediate robust
protection from secondary infection. TRM cells within the intestine and other tissues are …