The tissue diagnosis of amyloidosis and confirmation of fibril protein type, which are crucial
for clinical management, have traditionally relied on Congo red (CR) staining followed by …

Amyloidosis is caused by deposition in tissues of abnormal protein in a characteristic fibrillar
form. There are many types of amyloidosis, classified according to the soluble protein …

The diagnosis of the amyloid type ultimately depends on the examination of the amyloid
protein within the deposits. The role of immunohistochemistry–the current standard of care in …

The amyloidoses are a 'group'of disorders, all of which are associated with deposits that
display similar staining and ultrastructural features and are toxic to tissues. Many proteins …

Background Correct identification of the amyloidosis-causing protein is crucial for clinical
management. Recently the Mayo Clinic reported laser-capture microdissection (LCM) with …

Amyloidosis is a shared name for several rare, complex and serious diseases caused by
extra-cellular deposits of different misfolded proteins. Accurate characterization of the …

The clinical management of amyloidosis is based on the treatment of the underlying
etiology, and accurate identification of the protein causing the amyloidosis is of paramount …

Amyloidoses are characterized by deposition of misfolded proteins as β‐pleated sheet fibrils
in organs. Despite the similar morphologic appearance of fibrils, at least 28 different proteins …

Amyloidosis refers to a large spectrum of diseases, all characterized by the deposition of
extracellular misfolded proteins in the form of insoluble highly ordered amyloid fibrils in one …

Amyloidosis is a heterogeneous group of protein misfolding diseases characterized by
deposition of amyloid proteins. The kidney is frequently affected, especially by …