Exploiting the natural product potential of fungi with integrated-omics and synthetic biology approaches

ET Hillman, LR Readnour, KV Solomon - Current Opinion in Systems …, 2017 - Elsevier
Fungi are rich, underexploited reservoirs for natural products that may serve as medicines,
commodity chemicals, insecticides, pesticides and other valuable chemicals. Moreover, the …

Unearthing fungal chemodiversity and prospects for drug discovery

C Greco, NP Keller, A Rokas - Current opinion in microbiology, 2019 - Elsevier
Highlights•Fungi are an excellent source of drugs, and their full potential in producing
different metabolites is still largely untapped.•Several heterologous platforms have been …

Spatial and temporal control of fungal natural product synthesis

FY Lim, NP Keller - Natural product reports, 2014 - pubs.rsc.org
Covering: up to May 2014 Despite their oftentimes-elusive ecological role, fungal natural
products have, for better or worse, impacted our daily lives tremendously owing to their …

Unlocking fungal cryptic natural products

YM Chiang, KH Lee, JF Sanchez… - Natural product …, 2009 - journals.sagepub.com
Recent published sequencing of fungal genomes has revealed that these microorganisms
have a surprisingly large number of secondary metabolite pathways that can serve as …

From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

Engineering fungal secondary metabolism: a roadmap to novel compounds

DH Scharf, AA Brakhage - Journal of biotechnology, 2013 - Elsevier
Natural products play important roles not only in the environment but also as useful
compounds in various applications like in medicine or plant protection. An enormous …

Genomics-directed activation of cryptic natural product pathways deciphers codes for biosynthesis and molecular function

Y Tsunematsu - Journal of natural medicines, 2021 - Springer
Natural products, which can be isolated from living organisms worldwide, have played a
pivotal role in drug discovery since ancient times. However, it has become more challenging …

Fungal natural products galaxy: Biochemistry and molecular genetics toward blockbuster drugs discovery

K Bhattarai, ME Kabir, R Bastola, B Baral - Advances in genetics, 2021 - Elsevier
Secondary metabolites synthesized by fungi have become a precious source of inspiration
for the design of novel drugs. Indeed, fungi are prolific producers of fascinating, diverse …

Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining

CY Chiang, M Ohashi, Y Tang - Natural product reports, 2023 - pubs.rsc.org
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …