Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP
GOC Cory, R Cramer, L Blanchoin, AJ Ridley - Molecular cell, 2003 - cell.com
Wiskott-Aldrich syndrome protein (WASP) and neural (N)-WASP regulate dynamic actin
structures through the ability of their VCA domains to bind to and stimulate the actin …
structures through the ability of their VCA domains to bind to and stimulate the actin …
Arp2/3 complex is bound and activated by two WASP proteins
SB Padrick, LK Doolittle… - Proceedings of the …, 2011 - National Acad Sciences
Actin related protein 2/actin related protein 3 (Arp2/3) complex nucleates new actin filaments
in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome …
in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome …
Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin …
Neural Wiskott-Aldrich syndrome protein (N-WASP) is an essential regulator of actin
cytoskeleton formation via its association with the actin-related protein (Arp) 2/3 complex. It …
cytoskeleton formation via its association with the actin-related protein (Arp) 2/3 complex. It …
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate
R Rohatgi, HH Ho, MW Kirschner - The Journal of cell biology, 2000 - rupress.org
Neuronal Wiskott-Aldrich Syndrome protein (N-WASP) transmits signals from Cdc42 to the
nucleation of actin filaments by Arp2/3 complex. Although full-length N-WASP is a weak …
nucleation of actin filaments by Arp2/3 complex. Although full-length N-WASP is a weak …
Enhancement of branching efficiency by the actin filament-binding activity of N-WASP/WAVE2
The actin-related protein (Arp) 2/3 complex is an essential regulator of de novo actin filament
formation. Arp2/3 nucleates the polymerization of actin and creates branched actin filaments …
formation. Arp2/3 nucleates the polymerization of actin and creates branched actin filaments …
The Wiskott–Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex
Actin polymerization at the cell cortex is thought to provide the driving force for aspects of
cell-shape change and locomotion. To coordinate cellular movements, the initiation of actin …
cell-shape change and locomotion. To coordinate cellular movements, the initiation of actin …
Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex
JF Gaucher, C Maugé, D Didry, B Guichard… - Journal of Biological …, 2012 - ASBMB
Wiskott-Aldrich syndrome proteins (WASP) are a family of proteins that all catalyze actin
filament branching with the Arp2/3 complex in a variety of actin-based motile processes. The …
filament branching with the Arp2/3 complex in a variety of actin-based motile processes. The …
The verprolin-like central (vc) region of Wiskott-Aldrich syndrome protein induces Arp2/3 complex-dependent actin nucleation
K Hufner, HN Higgs, TD Pollard, C Jacobi… - Journal of Biological …, 2001 - ASBMB
Wiskott-Aldrich Syndrome protein (WASp) and related proteins stimulate actin filament
nucleation by Arp2/3 complex. The isolated C-terminal VCA domain of WASp …
nucleation by Arp2/3 complex. The isolated C-terminal VCA domain of WASp …
Physical mechanisms of signal integration by WASP family proteins
SB Padrick, MK Rosen - Annual review of biochemistry, 2010 - annualreviews.org
The proteins of the Wiskott-Aldrich syndrome protein (WASP) family are activators of the
ubiquitous actin nucleation factor, the Arp2/3 complex. WASP family proteins contain a C …
ubiquitous actin nucleation factor, the Arp2/3 complex. WASP family proteins contain a C …
Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex
TH Millard, SJ Sharp, LM Machesky - Biochemical Journal, 2004 - portlandpress.com
The assembly of a branched network of actin filaments provides the mechanical propulsion
that drives a range of dynamic cellular processes, including cell motility. The Arp2/3 complex …
that drives a range of dynamic cellular processes, including cell motility. The Arp2/3 complex …