A study of the ultrastructure of interphase chromosomes of frog erythrocytes and human
leucocytes suggested that the 500, 250 and 100 Å microfibrils observed in different …

Interphase and metaphase chromosomes have been isolated by spreading unfixed cells on
the Langmuir trough, followed by critical point drying. Both types of chromosomes prove to …

Nucleoids obtained from metaphase-arrested HeLa cells by gentle lysis in non-ionic
detergent and 2 M salt were prepared for electron microscopy by Kleinschmidt spreading …

Chromosomes isolated from human metaphase cells and resuspended in chromosome
isolation buffer were observed to be unstable and to disintegrate spontaneously at 4° C …

The higher order structure of chromosomes of Raji cells has been investigated with a field
emission type scanning electron microscope after the chromosomes had undergone surface …

SUPERCOILING of the DNA double helix in the deoxynucleo-histone fibril (100 Â in
diameter with a pitch of 120 Â) has been well documented by X-ray diffraction1–3. The main …

Electron micrographs of thin sections of metaphase chromosomes isolated from HeLa ceils
provide new insight into the higher-order arrangement of the nucleoprotein fiber …

The dimensions of chromatids in vivo and in fixed preparations of human chromosomes from
cultured lymphocytes were compared. The relative variation in diameter in relation to length …

Electron microscopy of HeLa metaphase nucleoids (ie whole metaphase cells exposed to 2
M salt and non-ionic detergent) spread by the Kleinschmidt technique, reveals a variety of …

The present note describes a morphological study of chromosomes extracted from human
resting nuclei, both of normal and leukaemic leucocytes. The isolated chromosomes were …