Calcification-induced stenosis or tearing is the principal cause of failure of clinical heart
valve bioprostheses fabricated from glutaraldehyde-pretreated porcine aortic valves and …

Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve
substitutes. Tissue valve calcification is initiated primarily within residual cells that have …

Glutaraldehyde-preserved stent-mounted porcine aortic valve bioprostheses are widely
used in the surgical management of valvular heart disease [3, 13, 16, 17]. Since 1971 …

Bioprostheses, composed of chemically treated animal tissue and termed heterografts or
xenografts, are the most widely used type of substitute heart valve. Their major limitation is …

Calcification, the major cause of bioprosthetic heart valve failures, is a serious clinical
problem with uncertain pathogenesis. The objectives of the present study were to define the …

Objective: Calcification is the most important cause of structural deterioration of
glutaraldehyde-fixed bioprosthetic valves. Devitalization of tissue favors calcium deposits in …

OBJECTIVE: We determined the possible effects of age, antimineralization treatments,
circulatory implant conditions, prosthesis design, and valve-related structural aspects on …

Clinical and experimental studies indicate that calcification of bioprosthetic valves depends
on host, implant, and biomechanical factors. The earliest mineral deposits in both clinical …

Attempts to replace diseased human valves with prostheses began more than 30 yrs ago.
Heart valve prostheses can be broadly classified into mechanical prostheses (made out of …

Background. Tissue properties may contribute to intrinsic calcification of bioprosthetic heart
valves. Phospholipids have been proposed as potential nucleation sites for calcification …