Abstract Type I interferon (IFN-I) exhibits broad-spectrum antiviral properties and is
commonly employed in clinical for the treatment of viral infections. In this study, we unveil …

Transcription factor IRF3-mediated type I interferon induction is essential for antiviral innate
immunity. We identified the deSUMOylating enzyme Sentrin/SUMO-specific protease …

STAT1 is a critical transcription factor for regulating host antiviral defenses. STAT1 activation
is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1) …

Type I interferons are broadly used for antiviral therapy in clinical. However, the IFNs-
mediated antiviral efficacy is commonly restricted by negative regulators. Here, we show that …

The innate immune responses are tightly regulated to ensure effective clearance of invading
pathogens and avoid excessive inflammation. Ubiquitination and deubiquitination are …

Deubiquitinating enzymes (DUBs) regulate antiviral immune response through targeting
DNA sensor signaling pathway members. As one of the DNA sensors, interferon (IFN)-γ …

Deubiquitinating enzymes (DUBs) play a pivotal role in regulating the antiviral immune
response by targeting members of the RLR signaling pathway. As a pivotal member of the …

Interferon (IFN) is a crucial first line of defense against viral infection. This cytokine induces
the expression of several IFN-Stimulated Genes (ISGs), some of which act as restriction …

Deubiquitinating enzymes (DUBs) are cysteine proteases that reverse the ubiquitination by
removing ubiquitins from the target protein. The human genome encodes∼ 100 potential …

Summary Type‐I interferons (IFN‐I) are used as common antiviral drugs for a range of viral
diseases in clinic. However, the antiviral efficacy of IFN‐I is largely restricted by negative …