After the fundamental discovery in 1956 that normal human cells contain 46 chromosomes,
clinical cytogenetics was born and studies into the relation of chromosomal defects and …

Chromosomes are the vehicles of genes, which are the functional units of a cell's nucleus. In
humans, there are more than 20,000 genes that are distributed among 46 chromosomes in …

With the advent of array‐based comparative genomic hybridization technology, the analog
cytogenetic analysis that has been used for the past 100 years could be replaced by the …

Exciting advances in fluorescence in situ hybridization and array-based techniques are
changing the nature of cytogenetics, in both basic research and molecular diagnostics …

The Philadelphia chromosome was the first chromosomal abnormality discovered in cancer
using the cytogenetics technique in 1960, and was consistently associated with chronic …

In the last decade a variety of fluorescence in situ hybridization (FISH) assays have been
developed. In this paper we present an overview on the currently available methods in …

The field of cytogenetics has focused on studying the number, structure, function and origin
of chromosomal abnormalities and the evolution of chromosomes. The development of …

Since the inception of clinical cytogenetics in the late 1950s, the field has witnessed the
evolution of multiple methodologies for the evaluation of chromosomal imbalances and …

Publisher Summary This chapter describes the detection of chromosomal aberrations by
means of molecular cytogenetics. In situ hybridization is a powerful tool in oncology allowing …

The development of microarray-based comparative genomic hybridization (array CGH)
methods represents a critical new advance in molecular cytogenetics. This new technology …