The inflammatory response following hypoxic-ischemia (HI) in the neonate is largely
unknown. Presently, the expression of microglial antigens and the β-amyloid precursor …

Activated microglia may contribute to the progression of neuronal injury after a wide range of
CNS insults. In this study, we used two complementary methods to evaluate acute changes …

In the present study, we tested whether the ongoing differentiation of microglia in the
immature brain results in more robust microglial activation and pro-inflammatory responses …

Background Neuroinflammation plays an important role in ischemic brain injury and
recovery, however the interplay between brain development and the neuroinflammatory …

Background: Neonatal encephalopathy induced by perinatal asphyxia is a serious condition
associated with high mortality and morbidity. Inflammation after the insult is thought to …

The mechanisms of neuronal injury after hypoxia–ischemia (HI) are different in the immature
and the adult brain, but microglia activation has not been compared. The purpose of this …

Immune cells display a high degree of phenotypic plasticity, which may facilitate their
participation in both the progression and resolution of injury-induced inflammation. The …

Brain ischemia triggers an inflammatory reaction that progresses for days to weeks and
seems to have a role in secondary progression of injury. Inflammation induces a complex …

There are many reports in experimental animals indicating that microglia are activated in the
dentate gyrus and hippocampus following hypoxic‐ischaemic brain injury. The hippocampi …

Neurogenesis is nearly completed after birth, whereas gliogenic activities remain intense
during the postnatal period in the developing rat cortex. These include involution of radial …