Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Covering: up to 2014 Large scale fungal genome sequencing has revealed a multitude of
potential natural product biosynthetic pathways that remain uncharted. Here we describe …

Microorganisms produce a wide range of natural products (NPs) with clinically and
agriculturally relevant biological activities. In bacteria and fungi, genes encoding successive …

Recent published sequencing of fungal genomes has revealed that these microorganisms
have a surprisingly large number of secondary metabolite pathways that can serve as …

Fungal natural products possess biological activities that are of great value to medicine,
agriculture and manufacturing. Recent metagenomic studies accentuate the vastness of …

For decades, fungi have been a source of US Food and Drug Administration–approved
natural products such as penicillin, cyclosporine, and the statins. Recent breakthroughs in …

Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Highlights•Fungi are an excellent source of drugs, and their full potential in producing
different metabolites is still largely untapped.•Several heterologous platforms have been …

Fungal natural products include antibiotics such as the penicillins, antirejection drugs such
as cyclosporins and cholesterollowering drugs such as the statins. High productivity of these …

Fungi are a prolific source of bioactive compounds, some of which have been developed as
essential medicines and life-enhancing drugs. Genome sequencing has revealed that fungi …