The ACCOMPLISH Trial: will first-line hypertension therapy change?

MJ Sorrentino - Current cardiology reports, 2011 - Springer
Aims: The ACCOMPLISH trial compared the rates of morbidity and mortality from
cardiovascular causes when two different combination therapies were used in patients with …

P-431: Design of the accomplish (avoiding cardiovascular events through combination therapy in patients living with systolic hypertension) trial

KA Jamerson, GL Bakris, JG Douglas… - American Journal of …, 2003 - search.proquest.com
Large-scale hypertension studies have indicated the benefits of achieving substantial
reductions in blood pressure (BP); however, most patients require combinations of …

Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: a …

MA Weber, GL Bakris, B Dahlöf, B Pitt… - Blood …, 2007 - Taylor & Francis
ACCOMPLISH is the first trial designed to compare the effects on major fatal and non‐fatal
cardiovascular endpoints of two forms of antihypertensive combination therapy: benazepril …

Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients

K Jamerson, MA Weber, GL Bakris… - … England Journal of …, 2008 - Mass Medical Soc
Background The optimal combination drug therapy for hypertension is not established,
although current US guidelines recommend inclusion of a diuretic. We hypothesized that …

The Avoiding Cardiovascular events through COMbination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: a comparison of first-line …

AB Weder - Expert Opinion on Pharmacotherapy, 2005 - Taylor & Francis
Although multidrug therapy is required in order to achieve good blood pressure control in
many hypertensives, there are no studies directly comparing fixed-dose combinations as …

[HTML][HTML] Will the Results of the ACCOMPLISH Trial Affect the Recommendations of JNC 8?

DL Cohen, RR Townsend - The Journal of Clinical Hypertension, 2009 - ncbi.nlm.nih.gov
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation,
and Treatment of High Blood Pressure (JNC 7) recommended using a thiazide diuretic as …

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C CARr - search.ebscohost.com
The article discusses a study of the use of benazepril plus amlodipine or
hydrochlorothiazide for hypertension in high-risk patients, published in a 2008 issue of the" …

Rationale and design of the avoiding cardiovascular events through combination therapy in patients living with systolic hypertension (ACCOMPLISH) trial: the first …

KA Jamerson, GL Bakris, CC Wun… - American journal of …, 2004 - academic.oup.com
Reducing blood pressure (BP) to target levels is a major priority in preventing clinical events
in hypertension. Typically this requires more than one drug, and recent guidelines on …

Avoiding Cardiovascular Complications in People Living With Systolic Hypertension, The ACCOMPLISH Trial

KA Jamerson - The FASEB Journal, 2010 - Wiley Online Library
Background ACCOMPLISH is the first trial to use combination therapy for the initial treatment
of high‐risk hypertensive patients. The single hypothesis, the combination of …

Comparison of benazepril plus amlodipine or hydrochlorothiazide in high-risk patients with hypertension and coronary artery disease

G Bakris, A Briasoulis, B Dahlof, K Jamerson… - The American journal of …, 2013 - Elsevier
Combination therapy with benazepril 40 mg and amlodipine 10 mg (B+ A) has been shown
to be more effective than benazepril 40 mg and hydrochlorothiazide (HCTZ) 25 mg (B+ H) in …