Specific generation of singlet oxygen through the russell mechanism in hypoxic tumors and GSH depletion by Cu‐TCPP nanosheets for cancer therapy

C Wang, F Cao, Y Ruan, X Jia, W Zhen… - Angewandte …, 2019 - Wiley Online Library
The generation of singlet oxygen (1O2) during photodynamic therapy is limited by the
precise cooperation of light, photosensitizer, and oxygen, and the therapeutic efficiency is …

Metal–organic framework (MOF) hybrid as a tandem catalyst for enhanced therapy against hypoxic tumor cells

J Liu, T Liu, P Du, L Zhang, J Lei - Angewandte Chemie, 2019 - Wiley Online Library
Encapsulation of active biomolecules and/or nanoparticles in metal–organic frameworks
(MOFs) remains a great challenge in biomedical applications. In this work, through a …

Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano‐MOF with CuII as the Active Center

W Zhang, J Lu, X Gao, P Li, W Zhang… - Angewandte Chemie …, 2018 - Wiley Online Library
In photodynamic therapy (PDT), the level of reactive oxygen species (ROS) produced in the
cell directly determines the therapeutic effect. Improvement in ROS concentration can be …

Copper/gold-modified porphyrinic metal–organic frameworks nanoprobes for enhanced photodynamic/chemodynamic therapy

J Zhang, L Chang, R Hao, G Zhang, T Liu, Z Li… - Chemical Engineering …, 2023 - Elsevier
Porphyrinic metal–organic frameworks (MOFs) had promising applications in the
photodynamic therapy (PDT) and chemodynamic therapy (CDT) of cancers, but the …

Ultra-thin metal–organic framework nanosheets for chemo-photodynamic synergistic therapy

R Zeng, T He, L Lu, K Li, Z Luo, K Cai - Journal of Materials Chemistry …, 2021 - pubs.rsc.org
Synergistic therapies, such as chemo-photodynamic therapy, have been growing fast
because of their efficacy against cancers. Although metal–organic frameworks have been …

Cell Membrane-Coated Porphyrin Metal–Organic Frameworks for Cancer Cell Targeting and O2-Evolving Photodynamic Therapy

D Zhang, Z Ye, L Wei, H Luo, L Xiao - ACS applied materials & …, 2019 - ACS Publications
Photodynamic therapy (PDT) has attracted great attention as an alternative tumor treatment
method. Unfortunately, it suffers from some limitations like poor targeting capability and …

H2S‐Activable MOF Nanoparticle Photosensitizer for Effective Photodynamic Therapy against Cancer with Controllable Singlet‐Oxygen Release

Y Ma, X Li, A Li, P Yang, C Zhang… - Angewandte Chemie …, 2017 - Wiley Online Library
Photodynamic therapy (PDT) has emerged as an important minimally invasive tumor
treatment technology. The search for an effective photosensitizer to realize selective cancer …

Nanoscale metal–organic framework for highly effective photodynamic therapy of resistant head and neck cancer

K Lu, C He, W Lin - Journal of the American Chemical Society, 2014 - ACS Publications
Photodynamic therapy (PDT) is an effective anticancer procedure that relies on tumor
localization of a photosensitizer followed by light activation to generate cytotoxic reactive …

Biomimetic platinum nanozyme immobilized on 2D metal–organic frameworks for mitochondrion-targeting and oxygen self-supply photodynamic therapy

Z Gao, Y Li, Y Zhang, K Cheng, P An… - … applied materials & …, 2019 - ACS Publications
Photodynamic therapy (PDT) as a noninvasive therapy mode has attracted considerable
attention in the field of oncotherapy. However, the PDT efficacy is restricted either by the …

Controlled generation of singlet oxygen in living cells with tunable ratios of the photochromic switch in metal–organic frameworks

J Park, Q Jiang, D Feng, HC Zhou - Angewandte Chemie, 2016 - Wiley Online Library
Abstract Development of a photosensitizing system that can reversibly control the generation
of singlet oxygen (1O2) is of great interest for photodynamic therapy (PDT). Recently several …