Objectives The effects of almokalant (4-[3-ethyl [3-(propylsulphinyl) propyl]-amino]-2-hydroxy-
propoxyj-benzonitrile), E-4031 (1-[2-(6-methyl-2-pyridyl)-ethyl]-4-(4-methylsulphonyl-amino …

The effect of class I anti-arrhythmic drugs, cibenzoline, mexiletine and flecainide, on the
delayed rectifier potassium current (IK) in guinea-pig ventricular myocytes was studied using …

Block of the delayed K+ current, i K, and the concomitant increase in refractoriness is
considered an alternative to a decrease of conduction in the treatment of reentry …

Objective: To elucidate the regional difference of the K+ current blocking effects of
methanesulfonanilide class III agents. Methods: Regional differences in action potential …

Objective: The aim was to study factors contributing to torsade de pointes in the acquired
long QT syndrome. Methods: Anaesthetised rabbits or cats were given a continuous infusion …

Background: The blockade of cardiac transmembrane potassium channels, which is
commonly seen with vanous antiarrhythmic drugs, plays an important role in their …

Objectives: To study the blocking effects of H 345/52 on ionic currents of rabbit ventricular
myocytes and how these features translate into a proarrhythmic potential. Methods: The …

Biophysical and pharmacological characteristics of the delayed rectifier K+ current (IK) of
rabbit sinoatrial (SA) node and atrioventricular (AV) node cells have been studied using the …

Objective: The objectives were (a) to evaluate the effects of WAY-123,398, a new class III
antiarrhythmic agent, on the action potential of canine Purkinje fibres in comparison with …

Block of the delayed rectifier potassium current, IK, by the class IC antiarrhythmic agent,
flecainide, and by the novel selective class III antiarrhythmic agent, E-4031, were compared …