Innate defense regulators (IDRs) are synthetic host-defense peptides (HDPs) with broad-
spectrum anti-infective properties, including immunomodulatory, anti-biofilm and direct …

Innate defense regulator-1002 (IDR-1002) is a synthetic peptide with promising
immunomodulatory and antibiofilm properties. An appreciable body of work exists around its …

Abstract Innate Defense Regulators (IDRs) are short synthetic peptides that target the host
innate immune system via an intracellular adaptor protein which functions at key signaling …

Innate defense regulators (IDRs) are synthetic immunomodulatory versions of natural host
defense peptides (HDP). IDRs mediate protection against bacterial challenge in the …

Host-defense peptides have drawn significant attention as new drugs or drug adjuvants to
combat multidrug-resistant bacteria. In this study, we report the development of cyclic …

A fundamentally new strategy for the treatment of infectious disease is the modulation of host
immune responses to enhance clearance of infectious agents and reduce tissue damage …

Macrophages play a critical role in the innate immune response. To respond in a rapid and
efficient manner to challenges in the micro-environment, macrophages are able to …

Non-natural amino acids can be incorporated into synthetic host defense peptides (HDPs) to
modulate their susceptibility to proteolytic degradation. However, the impact of non-natural …

Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now
widely recognized for their multifunctional roles in both the innate and adaptive immune …

Host defense (antimicrobial) peptides, produced by all complex organisms, typically contain
an abundance of positively charged and hydrophobic amino acid residues. A small synthetic …