Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce …

KL Seib, B Brunelli, B Brogioni, E Palumbo… - Infection and …, 2011 - Am Soc Microbiol
Neisseria meningitidis is a commensal of the human nasopharynx but is also a major cause
of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds …

Meningococcal factor H binding protein vaccine antigens with increased thermal stability and decreased binding of human factor H

R Rossi, M Konar, PT Beernink - Infection and Immunity, 2016 - Am Soc Microbiol
Neisseria meningitidis causes cases of bacterial meningitis and sepsis. Factor H binding
protein (FHbp) is a component of two licensed meningococcal serogroup B vaccines. FHbp …

Meningococcal factor H binding protein as immune evasion factor and vaccine antigen

S Principato, M Pizza, R Rappuoli - FEBS letters, 2020 - Wiley Online Library
Factor H binding protein (fHbp) is a key virulence factor of Neisseria meningitidis and a main
component of the two licensed vaccines against serogroup B meningococcus (Bexsero and …

Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease

LK McNeil, RJ Zagursky, SL Lin, E Murphy… - Microbiology and …, 2013 - Am Soc Microbiol
Neisseria meningitidis is a Gram-negative microorganism that exists exclusively in humans
and can cause devastating invasive disease. Although capsular polysaccharide-based …

Impaired immunogenicity of a meningococcal factor H-binding protein vaccine engineered to eliminate factor H binding

PT Beernink, J Shaughnessy, S Ram… - Clinical and Vaccine …, 2010 - Am Soc Microbiol
Meningococcal factor H-binding protein (fHbp) is a promising antigen that is part of two
vaccines in clinical development. The protein specifically binds human complement factor H …

Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity

S Giuntini, PT Beernink, DC Reason, DM Granoff - PloS one, 2012 - journals.plos.org
Background Meningococcal factor H binding protein (fHbp) is a promising vaccine
candidate. Anti-fHbp antibodies can bind to meningococci and elicit complement-mediated …

Nonfunctional variant 3 factor H binding proteins as meningococcal vaccine candidates

S van der Veen, S Johnson, I Jongerius… - Infection and …, 2014 - Am Soc Microbiol
Neisseria meningitidis is a human-specific pathogen and leading cause of meningitis and
septicemia. Factor H binding protein (fHbp), a virulence factor which protects N. meningitidis …

Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess …

PT Beernink, J Shaughnessy, H Stefek… - Clinical and Vaccine …, 2014 - Am Soc Microbiol
Neisseria meningitidis causes disease only in humans. An important mechanism underlying
this host specificity is the ability of the organism to resist complement by recruiting the …

Importance of inhibition of binding of complement factor H for serum bactericidal antibody responses to meningococcal factor H-binding protein vaccines

M Konar, DM Granoff, PT Beernink - The Journal of infectious …, 2013 - academic.oup.com
Abstract Background. Factor H (fH) binding protein (fHbp) is part of vaccines developed for
prevention of meningococcal serogroup B disease. More than 610 fHbp amino acid …

Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines

WX Yee, G Barnes, H Lavender, CM Tang - Trends in Microbiology, 2023 - cell.com
Neisseria meningitidis is a human-adapted pathogen that causes meningitis and sepsis
worldwide. N. meningitidis factor H-binding protein (fHbp) provides a mechanism for …