The genomes of warm-blooded vertebrates are mosaics of long DNA segments (> 300 kb,
on the average), the isochores, homogeneous in GC levels, which belong to a small number …

The genomic organization of most of the human dystrophin gene has not been defined at
single-exon level, owing to its enormous size (2300 kb). By taking advantage of a YAC …

The enormous size of the human dystrophin gene (2300 kb) has so far hindered the analysis
of its organization and the characterization at the genomic level of the deletion and …

The organization of the human dystrophin gene into loop domains has been studied using
two different experimental approaches: excision of DNA loops mediated by nuclear matrix …

Application of a novel vectorette PCR approach to defining intron-exon boundaries has
permitted completion of analysis of the exon structure of the largest and most complex …

Analysis of the exon–intron organization of the human dystrophin gene has been hampered
by its enormous size. By using a YAC-based exon mapping approach and long PCR, we …

Large intragenic deletions within the DMD locus account for about 60% of Duchenne and
Becker muscular dystrophy patients. Two deletion hot-spots have been described in the …

About one third of Duchenne muscular dystrophy (DMD) patients have no gross DNA
rearrangements in the dystrophin gene detectable by Southern blot analysis or multiplex …

The region of the dystrophin gene containing introns 45–50 is characterized by a high rate of
recombination events that give rise to large deletions causing dystrophinopathy. The …

Although large deletions comprise 65% of the mutations that underlie most cases of
Duchenne and Becker muscular dystrophies, the DNA sequence characteristics of the …