Introduction Wound healing after myocardial infarction (MI) is mediated by different cell
types, secreted proteins, components of the extracellular matrix (ECM) and, as increasing …

Rationale: A rapid and massive influx of inflammatory cells occurs into ischemic area after
myocardial infarction (MI), resulting in local release of cytokines and growth factors. Yet, the …

During myocardial ischemia, timely reperfusion is critical to limit infarct area and the overall
loss of cardiac contractile function. However, reperfusion further exacerbates the damage of …

Abstract Rationale Extracellular vesicles (EVs) derived exogenously from pluripotent stem
cells or endogenously from healthy human serum exert cardioprotective effects after injury …

Myocardial ischemia-related disorders constitute a major health problem, being a leading
cause of death in the world. Upon ischemia, tissue remodeling processes come into play …

Myocardial ischaemia is associated with an exacerbated inflammatory response, as well as
with a deregulation of intercellular communication systems. Macrophages have been …

The biological relevance of extracellular vesicles (EV) released in an ischemia/reperfusion
setting is still unclear. We hypothesized that the inflammatory microenvironment prevents …

Abstract Background Extracellular vesicles (EVs) derived from various cell sources exert
cardioprotective effects during cardiac ischemic injury. Our previous study confirmed that …

Simple Summary A heart attack may lead to the remodelling of the cardiac muscle, which
negatively affects patient's prognosis. At present, the mechanisms of cardiac remodelling …

Acute myocardial infarction (AMI) results from vulnerable plaque rupture, causing ischemic
cardiomyocyte necrosis and intense inflammation. Paradoxically, this inflammation releases …