Multidimensional chromatography offers enhanced chromatographic resolution and peak
capacity, which are crucial for analyzing complex samples. This study presents a novel …

The confident identification and in-depth profiling of molecular lipid species remain to be a
challenge in lipidomics analysis. In this work, an off-line two-dimensional mixed-mode and …

Lipidomics is a critical part of metabolomics and aims to study all the lipids within a living
system. We present here the development and evaluation of a sensitive capillary UPLC-MS …

Lipids have been analyzed in applications including drug discovery, disease etiology
elucidation, and natural products. The chemical and structural diversity of lipids requires a …

Detailed analysis of lipid species can be challenging due to their structural diversity and
wide concentration range in cells, tissues, and biofluids. To address these analytical …

Multidimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) has become a
foundational analytical technology platform among current lipidomics practices due to its …

The goal of untargeted lipidomics is to have high throughput, yet comprehensive and
unambiguous identification and quantification of lipids. Novel stationary phases in LC …

Comprehensive characterization of the lipidome remains a challenge requiring development
of new analytical approaches to expand lipid coverage in complex samples. In this work …

Natural lipidomes are characterized by extremely high complexity and dynamic range of
lipid concentrations. Furthermore, high diversity of lipid physicochemical properties requires …

Since our last comprehensive review on multi‐dimensional mass spectrometry‐based
shotgun lipidomics (Mass Spectrom. Rev. 24 (2005), 367), many new developments in the …