Multiparametric MRI of epiphyseal cartilage necrosis (osteochondrosis) with histological validation in a goat model

L Wang, MJ Nissi, F Tóth, J Shaver, CP Johnson… - PloS one, 2015 - journals.plos.org
Purpose To evaluate multiple MRI parameters in a surgical model of osteochondrosis (OC)
in goats. Methods Focal ischemic lesions of two different sizes were induced in the …

In vivo visualization using MRI T2 mapping of induced osteochondrosis and osteochondritis dissecans lesions in goats undergoing controlled exercise

F Tóth, FH David, E LaFond, L Wang… - Journal of …, 2017 - Wiley Online Library
In vivo visualization of subclinical osteochondrosis (OC) lesions, characterized by necrosis
of epiphyseal growth cartilage, is necessary to clarify the pathogenesis of this disease …

[HTML][HTML] Surgical induction, histological evaluation, and MRI identification of cartilage necrosis in the distal femur in goats to model early lesions of osteochondrosis

F Tóth, MJ Nissi, L Wang, JM Ellermann… - Osteoarthritis and …, 2015 - Elsevier
Objective Identify and interrupt the vascular supply to portions of the distal femoral articular-
epiphyseal cartilage complex (AECC) in goat kids to induce cartilage necrosis, characteristic …

Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans

L Wang, MJ Nissi, F Toth, CP Johnson… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose To use quantitative susceptibility mapping (QSM) to investigate changes in
cartilage canals in the distal femur of juvenile goats after their surgical transection. Methods …

Histological confirmation and biological significance of cartilage canals demonstrated using high field MRI in swine at predilection sites of osteochondrosis

F Tóth, MJ Nissi, J Zhang, M Benson… - Journal of …, 2013 - Wiley Online Library
Cartilage canal vessels in epiphyseal cartilage have a pivotal role in the pathogenesis of
osteochondrosis/osteochondritis dissecans. The present study aimed to validate high field …

Micro-computed tomography of early lesions of osteochondrosis in the tarsus of foals

K Olstad, V Cnudde, B Masschaele, R Thomassen… - Bone, 2008 - Elsevier
INTRODUCTION: Osteochondrosis (OC) is an important developmental orthopedic disease
of human and equine patients. The disease is defined as a focal disturbance in enchondral …

Femoral epiphyseal cartilage matrix changes at predilection sites of equine osteochondrosis: quantitative MRI, second‐harmonic microscopy, and histological findings

G Martel, CA Couture, G Gilbert… - Journal of …, 2016 - Wiley Online Library
Osteochondrosis is an ischemic chondronecrosis of epiphyseal growth cartilage that results
in focal failure of endochondral ossification and osteochondritis dissecans at specific sites in …

Differences in the vascular tree of the femoral trochlear growth cartilage at osteochondrosis‐susceptible sites in foals revealed by SWI 3T MRI

G Martel, S Kiss, G Gilbert… - Journal of …, 2016 - Wiley Online Library
Focal ischemic chondronecrosis of epiphyseal growth cartilage (EGC) during endochondral
ossification is believed to be a key early event on the pathway to osteochondrosis (OC) in …

High resolution MRI imaging at 9.4 Tesla of the osteochondral unit in a translational model of articular cartilage repair

L Goebel, A Müller, A Bücker, H Madry - BMC musculoskeletal disorders, 2015 - Springer
Background Non-destructive structural evaluation of the osteochondral unit is challenging.
Here, the capability of high-field magnetic resonance imaging (μMRI) at 9.4 Tesla (T) was …

An update on the pathogenesis of osteochondrosis

K Olstad, S Ekman, CS Carlson - Veterinary pathology, 2015 - journals.sagepub.com
Osteochondrosis is defined as a focal disturbance in endochondral ossification. The
cartilage superficial to an osteochondrosis lesion can fracture, giving rise to fragments in …