Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and has the
second highest mortality rate globally. Thanks to the advent of next-generation sequencing …

Abstract Background Inactivation of the Fanconi anemia (FA) pathway through defects in
one of 13 FA genes occurs at low frequency in various solid cancer entities among the …

Colorectal cancer (CRC) is one of the most common neoplasms in the world. Fanconi
anemia (FA) is a very rare genetic disease causing bone marrow failure, congenital growth …

Genetic or epigenetic inactivation of the pathway formed by the Fanconi Anemia (FA)
proteins occurs in several cancer types, including head and neck squamous cell carcinomas …

Background & Aims: How specifically to treat pancreatic and other cancers harboring
Fanconi anemia gene mutations has raised great interest recently, yet preclinical studies …

Monoubiquitination of FANCD2 is a central step in the activation of the Fanconi anemia (FA)
pathway after DNA damage. Defects in the FA pathway centered around FANCD2 not only …

An extremely high cancer incidence and the hypersensitivity to DNA crosslinking agents
associated with Fanconi Anemia (FA) have marked it to be a unique genetic model system to …

Prostate cancer is one of the leading causes of death among men worldwide, and thus,
research on the genetic factors enabling the formation of treatment-resistant cancer cells is …

Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …

Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least
one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and …