Suppression of transient outward potassium currents in mouse ventricular myocytes by imidazole antimycotics and by glybenclamide

MJ Hernandez-Benito, R Macianskiene… - The Journal of …, 2001 - Elsevier
The whole-cell patch-clamp technique was used in adult mouse ventricular myocytes at 22°
C to study the transient outward current (I to) and its sensitivity to the antimycotics …

Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes

U Jahnel, P Klemm, H Nawrath - Naunyn-Schmiedeberg's archives of …, 1994 - Springer
The mechanism of drug-induced inhibition of the transient outward current, I to, has been
investigated in rat ventricular myocytes using the whole cell patch clamp technique. I to was …

Characterization of 4-aminopyridine block of the transient outward K+ current in adult rat ventricular myocytes

NA CASTLE, MT SLAWSKY - The Journal of pharmacology …, 1993 - jpet.aspetjournals.org
The blocking action of 4-aminopyridine (4-AP) on the transient outward K+ current (I TO) in
isolated rat ventricular myocytes was studied using the whole-cell configuration of the patch …

Effect of disopyramide on potassium currents in rabbit ventricular myocytes

L Virág, A Varró, JG Papp - Naunyn-Schmiedeberg's archives of …, 1998 - Springer
Abstract The effects of disopyramide (1–30 μM) on the 4-aminopyridine sensitive transient
outward current (I to), on the rapid component of the delayed rectifier potassium current (I Kr) …

Actions of the anti‐oestrogen agent clomiphene on outward K+ currents in rat ventricular myocytes

JJ Borg, JC Hancox, DS Hogg… - Clinical and …, 2004 - Wiley Online Library
The effects of clomiphene (CLM) on cardiac outward K+ current components from rat
isolated ventricular myocytes were investigated using the whole‐cell patch‐clamp …

Activation of protein kinase A partially reverses the effects of 2, 3-butanedione monoxime on the transient outward K+ current of rat ventricular myocytes

X Yong-Fu, JJ McArdle - Life sciences, 1995 - Elsevier
The transient outward K+ current (Ito) was assessed in single rat ventricular myocytes with
the whole-cell patch-clamp technique. Extracellular application of the chemical phosphatase …

Different inhibition patterns of tedisamil for fast and slowly inactivating transient outward current in rat ventricular myocytes

F Berger, U Borchard, D Hafner, TM Weis - … -Schmiedeberg's archives of …, 1998 - Springer
Tedisamil has been described as a selective inhibitor of a fast inactivating transient outward
current (i to, f) in rat ventricular myocytes. Because recent reports demonstrated the …

[PDF][PDF] Use-dependent features of 4-aminopyridine block of transient outward current in rat ventricular myocytes

G Christé, M Simurdova, J Simurda - General Physiology and Biophysics, 1995 - gpb.sav.sk
The inhibition of the calcium-independent transient outward current (ito) by the widely used
blocker 4-aminopyridine (4-AP) was studied in adult Wistar rat ventricular myocytes …

Imipramine blocks rapidly activating and delays slowly activating K+ current activation in guinea pig ventricular myocytes.

C Valenzuela, J Sánchez-Chapula, E Delpon… - Circulation …, 1994 - Am Heart Assoc
Imipramine is a tricyclic antidepressant drug that also exhibits antiarrhythmic effects and
whose clinical spectrum of activity is similar to that of quinidine. It has been previously …

[PDF][PDF] Effect of ajmaline on transient outward current in rat ventricular myocytes

M Bébarová, P Matejovic, M Pasek, M Simurdova… - Gen Physiol …, 2005 - Citeseer
The mechanism of ajmaline-induced inhibition of the transient outward current (Ito) has been
investigated in right ventricular myocytes of rat using the whole cell patch clamp technique …