Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-κB signaling, and promoting fibroblast-to …

X He, SH Young, D Schwegler-Berry… - Chemical research in …, 2011 - ACS Publications
Carbon nanotubes (CNTs) are novel materials with unique electronic and mechanical
properties. The extremely small size, fiberlike shape, large surface area, and unique surface …

Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes

J Dong, DW Porter, LA Batteli, MG Wolfarth… - Archives of …, 2015 - Springer
Multi-walled carbon nanotubes (MWCNT) are new materials with a wide range of industrial
and commercial applications. However, their nano-scaled size and fiber-like shape render …

Pulmonary toxicity and fibrogenic response of carbon nanotubes

A Manke, L Wang, Y Rojanasakul - Toxicology mechanisms and …, 2013 - Taylor & Francis
Carbon nanotubes (CNTs) have been a subject of intensive research for a wide range of
applications. However, because of their extremely small size and light weight, CNTs are …

Mechanisms of carbon nanotube‐induced pulmonary fibrosis: a physicochemical characteristic perspective

KS Duke, JC Bonner - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Carbon nanotubes (CNTs) are engineered nanomaterials (ENMs) with numerous beneficial
applications. However, they could pose a risk to human health from occupational or …

Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses

N Azad, AKV Iyer, L Wang, Y Liu, Y Lu… - …, 2013 - Taylor & Francis
Single-walled carbon nanotubes (SWCNTs) are fibrous nanoparticles that are being used
widely for various applications including drug delivery. SWCNTs are currently under special …

Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspects

J Muller, F Huaux, A Fonseca, JB Nagy… - Chemical research in …, 2008 - ACS Publications
Experimental studies indicate that carbon nanotubes (CNTs) have the potential to induce
adverse pulmonary effects, including alveolitis, fibrosis, and genotoxicity in epithelial cells …

Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF‐β/Smad signaling pathway

P Wang, X Nie, Y Wang, Y Li, C Ge, L Zhang, L Wang… - Small, 2013 - Wiley Online Library
Multiwall carbon nanotubes (MWCNTs) have been widely used in many disciplines due to
their unique physical and chemical properties, but have also raised great concerns about …

Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis

J Dong, Q Ma - Nanotoxicology, 2018 - Taylor & Francis
Pulmonary exposure to carbon nanotubes (CNTs) induces fibrosing lesions in the lungs that
manifest rapid-onset inflammatory and fibrotic responses, leading to chronic fibrosis in …

Integration of inflammation, fibrosis, and cancer induced by carbon nanotubes

J Dong, Q Ma - Nanotoxicology, 2019 - Taylor & Francis
Carbon nanotubes (CNTs) are nanomaterials with unique physicochemical properties that
are targets of great interest for industrial and commercial applications. Notwithstanding …

Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts

L Wang, RR Mercer, Y Rojanasakul, A Qiu… - Journal of Toxicology …, 2010 - Taylor & Francis
Nanomaterials, including single-walled carbon nanotubes (SWCNT), are being developed
for a variety of commercial products. However, adverse health effects attributed to these new …