Spared nerve injury (SNI) altered the action potential (AP) output of lamina I spino-
parabrachial neurons (SPNs) without affecting their resting potential or membrane …

Lamina I spino-parabrachial neurons (SPNs) receive peripheral nociceptive input, process it
and transmit to the supraspinal centres. Although responses of SPNs to cutaneous receptive …

Plasticity of inhibitory transmission in the spinal dorsal horn (SDH) is believed to be a key
mechanism responsible for pain hypersensitivity in neuropathic pain syndromes. We …

Adequate pain sensitivity requires a delicate balance between excitation and inhibition in
the dorsal horn of the spinal cord. This balance is severely impaired in neuropathy leading …

Recent evidence indicates that neuropathic pain from partial peripheral nerve injury is
maintained by electrophysiologically abnormal signals from injured sensory neurons. To …

Key points Spinal cord lamina I neurons receiving dense input from nociceptors and
projecting to the parabrachial area at the ponto‐mesencephalic junction form the major …

Previously we reported that the cuff model of peripheral neuropathy, in which a 2 mm
polyethylene tube is implanted around the sciatic nerve, exhibits aspects of neuropathic pain …

Primary sensory neurons with myelinated axons were examined in vitro in excised whole
lumbar dorsal root ganglia (DRGs) taken from adult rats up to 9 days after tight ligation and …

Nociceptive pain alerts the body to potential or actual tissue damage. By contrast,
neuropathic or" noninflammatory" pain, which results from injury to the nervous system …

Previous studies demonstrated that peripheral nerve injury induced excessive nociceptive
response of spinal cord dorsal horn neurons and such change has been proposed to reflect …