The question as to how the strands of chromatin are packed into the eukaryotic nucleus has
intrigued biologists and biochemists for many years. Although there is ample space in the …

Both intact and nuclease-isolated chromatin fibers have been examined at different degrees
of salt-induced compaction, using a variety of preparation techniques. The results suggest …

The" 30-nm" chromatin fibers, as observed in eukaryotic nuclei, are considered a discrete
level in a hierarchy of DNA folding. At present, there is considerable debate as to how the …

Chromatin is the nucleoprotein complex found in the nucleus of all eukaryotic cells. It
undergoes obvious changes during the cell cycle and varies in form from the highly compact …

The DNA helix is coiled in the nucleohistone fiber in a nonrandom, precise manner. At one
end of the coiling spectrum we have the nucleosome and at the other end the metaphase …

The last years have witnessed rapid progress in our understanding of chromatin structure at
the nucleosome or beads-on-a-string level (Elgin and Weintraub 1975; Kornberg 1977) …

The predominant view of chromatin structure is that the beaded chain of nucleosomes is
folded into a symmetrical helical fibre. Recently, however, direct evidence from cryoelectron …

We show that the mechanism by which chromatin displaying higher-order structure is
usually isolated from nuclei involves a transition to an extended nucleosomal arrangement …

The structure of the “30nm chromatin fiber”, as observed in vitro, has been a matter of
controversy for 30 years. Recent studies with new and more powerful techniques give some …

In this study, electron tomograms of plunge-frozen isolated chromatin in both open and
compacted form were recorded. We have resolved individual nucleosomes in these …