In a previous study we identified active Notch signaling in key cellular events occurring at
adult spermatogenesis. In this study, we evaluated the function of Notch signaling in …

NOTCH1 is a member of the NOTCH receptor family, a group of single-pass trans-
membrane receptors. NOTCH signaling is highly conserved in evolution and mediates …

The transcription and expression patterns of Notch pathway components (Notch 1–3, Delta1
and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT …

Spermatogenesis is an elaborately regulated system dedicated to the continuous production
of spermatozoa via the genesis of spermatogonia. In this process, a variety of genes are …

Notch signaling components have long been detected in Sertoli and germ cells in the
developing and mature testis. However, the role of this pathway in testis development and …

Spermatozoa undergo sequential maturation changes during their transit along the
epididymis. These changes are modulated by the epididymal epithelium and require a finely …

Members of the Notch gene family have been shown to play an important role in the control
of cell fate in many developmental systems. We hypothesized that the fate of the male germ …

The expression pattern of Notch family receptors during mouse spermatogenesis was
examined by immunohistochemistry. The entire cytoplasm of spermatogonia, spermatocytes …

Stable and sustainable spermatogenesis is supported by the strict regulation of self-renewal
and differentiation of spermatogonial stem cells (SSC), which are a rare population of …

Background Notch signaling pathway is involved in contact‐dependent communication
between the cells of seminiferous epithelium, and its proper activity is important for …