Biochemical and genetic studies place the amyloid precursor protein (APP) at the center
stage of Alzheimer's disease (AD) pathogenesis. Although mutations in the APP gene lead …

A critical role of the amyloid precursor protein (APP) in Alzheimer's disease (AD)
pathogenesis has been well established. However, the physiological function of APP …

Although abnormal processing of amyloid precursor protein (APP) leads to early onset of
Alzheimer's disease, the normal function of this protein is poorly understood. APP is widely …

The amyloid precursor protein family (APP/APLPs) has essential roles for neuromuscular
synapse development and for the formation and plasticity of synapses within the CNS …

The key role of APP in the pathogenesis of Alzheimer disease is well established. However,
postnatal lethality of double knockout mice has so far precluded the analysis of the …

Although abnormal processing of β-amyloid precursor protein (APP) has been implicated in
the pathogenic cascade leading to Alzheimer's disease, the normal function of this protein is …

The amyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer's
disease (AD), as proteolytical cleavage of APP gives rise to the β-amyloid peptide which is …

The amyloid precursor protein (APP) is well known to be involved in the pathophysiology of
Alzheimer's disease (AD) via its cleavage product amyloid ß (Aß). However, the …

Senile plaques, a hallmark of Alzheimer's disease (AD), contain amyloid β-peptide (Aβ),
which is generated from the larger amyloid β protein precursor (APP). In addition to APP …

The amyloid precursor protein (APP) is critical in the pathogenesis of Alzheimer's disease.
The question of its normal biological function in neurons, in which it is predominantly located …