Huntington's disease (HD) is caused by a genetic mutation that results in a polyglutamine
expansion in huntingtin. The time course of neuronal loss in the HD striatum and other …

Huntington disease (HD) is an inherited neurological disorder caused by a polyglutamine
expansion in the protein huntingtin and is characterized by selective neurodegeneration that …

Huntingtin is the protein involved in Huntington disease (HD), an inherited
neurodegenerative disease. Research activities have focused on the abnormal functions of …

Huntington's Disease is an adult-onset dominant heritable disorder characterized by
progressive psychiatric disruption, cognitive deficits, and loss of motor coordination. It is …

Huntington Disease (HD) results from polyglutamine expansion within the N-terminus of
huntingtin. We have produced yeast artificial chromosome (YAC) transgenic mice …

Huntingtin expression was examined by Western blot and immunoprecipitation studies of
lymphoblastoid cell lines from Huntington's disease (HD) homozygotes, heterozygotes, and …

Huntington's disease (HD) is caused by a mutation in the gene encoding for huntingtin
resulting in selective neuronal degeneration. Because HD is an autosomal dominant …

The immunohistochemical localization of huntingtin was examined in the Huntington's
disease (HD) brain with an antibody that recognizes the wild‐type and mutant proteins …

Huntington disease (HD) is caused by expansion of a glutamine repeat in the amino-
terminal region of huntingtin. Despite its widespread expression, mutant huntingtin induces …

Huntington's disease (HD) is caused by a polyglutamine expansion in the amino-terminal
region of huntingtin. Mutant huntingtin is proteolytically cleaved by caspases, generating …