Background: Offset analgesia (OA) is an increasingly described phenomenon to measure
endogenous pain inhibition, in which a greater decrease in pain intensity is experienced …

Objectives Offset analgesia (OA) induces a brief pain inhibition and studies suggest OA
impairment in patients with chronic pain when compared to healthy subjects. Conditioned …

Objective: Offset analgesia (OA) is a test paradigm increasingly used to estimate
endogenous pain modulation characterized by a disproportionally profound analgesia after …

Background Offset analgesia (OA) is a pain‐inhibiting mechanism, defined as a
disproportionately large decrease in pain perception in response to a discrete decrease in …

Background Offset analgesia (OA) is a disproportionally large decrease in the pain
perception in response to a small decrease in the stimulation intensity. Traditionally, heat …

Background Offset analgesia (OA) is characterized by a disproportionately large reduction in
pain following a small decrease in noxious stimulation and is based on temporal pain …

Background Conditioned pain modulation (CPM) and offset analgesia quantify impairment
of endogenous pain modulation, but magnitude and reliability vary broadly between studies …

Offset analgesia (OA) represents a disproportionately large decrease of pain perception
after a brief, temporary increment of thermal pain stimulus and was reported attenuated in …

Abstract Background Offset Analgesia (OA) can be evoked by a three‐heat‐stimulus train
(T1‐T2‐T3), with T1 (5 s) and T3 (20 s) having the same temperature (eg 48° C) and T2 (5 s) …

Objective Endogenous pain modulation can be quantified through the use of various
paradigms. Commonly used paradigms include conditioned pain modulation (CPM), offset …