Curcumin attenuates on carbon tetrachloride-induced acute liver injury in mice via modulation of the Nrf2/HO-1 and TGF-β1/Smad3 pathway

X Peng, C Dai, Q Liu, J Li, J Qiu - Molecules, 2018 - mdpi.com
This study aimed to investigate the protective effect of curcumin against carbon tetrachloride
(CCl4)-induced acute liver injury in a mouse model, and to explain the underlying …

Curcumin protects against acute liver damage in the rat by inhibiting NF-κB, proinflammatory cytokines production and oxidative stress

K Reyes-Gordillo, J Segovia, M Shibayama… - … et Biophysica Acta (BBA …, 2007 - Elsevier
Curcumin, an anti-inflammatory and antioxidant compound, was evaluated for its ability to
suppress acute carbon tetrachloride-induced liver damage. Acute hepatotoxicity was …

Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression

C Tu, Q Yao, B Xu, J Wang, C Zhou, S Zhang - Food and chemical …, 2012 - Elsevier
The aim of the study was to investigate the effect of curcumin on the liver fibrosis induced by
carbon tetrachloride (CCl4) in rats, and to elucidate its underlying molecular mechanisms …

[HTML][HTML] Curcumin protects against hepatic ischemia/reperfusion induced injury through inhibiting TLR4/NF-κB pathway

L Wang, N Li, D Lin, Y Zang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract The TLR4/NF-κB pathway had important roles in hepatic ischemia/reperfusion (I/R)
injury. In this study, we reported a protective effect of curcumin against hepatic I/R injury via …

Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon …

Q Yao, B Xu, J Wang, H Liu, S Zhang, C Tu - BMC complementary and …, 2012 - Springer
Background At present there is no effective and accepted therapy for hepatic fibrosis.
Transforming growth factor (TGF)-β1 signaling pathway contributes greatly to hepatic …

Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress

GH Lee, HY Lee, MK Choi, HW Chung, SW Kim… - BMC research …, 2017 - Springer
Abstract Background The Curcuma longa L.(CLL) rhizome has long been used to treat
patients with hepatic dysfunction. CLL is a member of the ginger family of spices that are …

[HTML][HTML] Protective effects of curcumin against chronic alcohol-induced liver injury in mice through modulating mitochondrial dysfunction and inhibiting endoplasmic …

B Wang, X Gao, B Liu, Y Li, M Bai, Z Zhang… - Food & Nutrition …, 2019 - ncbi.nlm.nih.gov
Background Curcumin is a major active ingredient extracted from powdered dry rhizome of
Curcuma longa. In Ayurveda and traditional Chinese medicine, it has been used as a …

Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression

C Tu, B Han, Q Yao, Y Zhang, H Liu, S Zhang - International …, 2012 - Elsevier
Curcumin has antiviral, antioxidant, and anti-inflammatory properties. However, the
hepatoprotective effects and molecular mechanisms of curcumin on acute liver injury have …

[HTML][HTML] Curcumin attenuates chronic ethanol-induced liver injury by inhibition of oxidative stress via mitogen-activated protein kinase/nuclear factor E2-related factor 2 …

ZE Xiong, WG Dong, BY Wang, QY Tong… - Pharmacognosy …, 2015 - ncbi.nlm.nih.gov
Objective: This study aimed to investigate the protective effect of curcumin on chronic
ethanol-induced liver injury in mice and to explore its underlying mechanisms. Materials and …

Folic acid and melatonin ameliorate carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats

H Ebaid, SAE Bashandy, IM Alhazza, A Rady… - Nutrition & …, 2013 - Springer
This study investigated the protective effects of melatonin and folic acid against carbon
tetrachloride (CCl4)-induced hepatic injury in rats. Oxidative stress, liver function, liver …