The polymerase enzyme hardly differentiates between thymine and difluorotoluene
nucleotides with respect to the replication selectivity. X‐ray structure analysis show the …

The physical and chemical factors that allow DNA to perform its functions in the cell have
been studied for several decades. Recent advances in the synthesis and manipulation of …

The mechanisms of DNA synthesis by DNA polymerase enzymes have come under
intensive study recently because of their close biological connections to cancer.[1] …

Based on a series of elegant experiments, Kool and coworkers [1] concluded that not
Watson±Crick hydrogen bonding but steric effects, that is, the shape of DNA bases is mainly …

▪ Abstract Various physicochemical factors influence DNA replication fidelity. Since it is now
known that Watson-Crick hydrogen bonds are not necessary for efficient and selective …

The principles governing the replication fidelity of genomes are not fully understood yet.
Watson and Crick's base‐pairing principle for matched deoxyribonucleotide (DNA) bases …

That hydrogen bonds play a central role in forming Watson–Crick (W–C) AT and GC base
pairs is a fundamental paradigm dating from the discovery of the structure of DNA in 1953. In …

The survival of an organism requires precise duplication of the genome. Error frequencies
are typically only 10-9 to 10 10 per base replicated. The bio chemical problem posed by this …

Replication fidelity: How do DNA polymerases ensure selectivity? Further insights into
interactions between a DNA polymerase and the sugar moiety of the template nucleotide …

DNA polymerase enzymes make an error only once per 10 4–10 5 initial nucleotide
insertions during DNA replication. Most currently held models of this high fidelity cite the …