Ultrastructural cytochemistry has been, for many years now, a major tool for investigating
structure–function relationships in the cell nucleus. It has been essential in approaching the …

For many years, ultrastructural cytochemistry has been a major tool for investigating the
relationships between the structure and the functions of the cell nucleus. This article shortly …

Publisher Summary This chapter integrates the current understanding of the major nuclear
functions (replication of DNA, transcription of RNA, transport of RNA and other …

Until recently our knowledge about the structural and functional organization of the cell
nucleus was very limited. Recent technical developments in the field of ultrastrcutural …

This electron microscopy review documents the in situ cytochemical localization of important
nuclear structures and relates this to the important nuclear functions of RNA transcription …

The cell nucleus is a highly compartmentalized structure. In this review we describe
controversial views on higher order chromatin organization from the level of higher order …

Ultrastructural studies conducted in situ using conventional transmission electron
microscopy have had relatively little impact on defining the structural organization of …

Advances in the specific fluorescent labeling of chromatin in fixed and living human cells in
combination with three-dimensional (3D) and 4D (space plus time) fluorescence microscopy …

In this review we describe major contributions of light and electron microscopic approaches
to the present understanding of functional nuclear architecture. The large gap of knowledge …

It is evident that primary DNA sequences, that define genomes, are responsible for genome
functions. However, the functional properties of chromatin are additionally regulated by …