The IFN immune system comprises type I, II, and III IFNs, signals through the JAK-STAT
pathway, and plays central roles in host defense against viral infection. Posttranslational …

Deubiquitinating enzymes (DUBs) are cysteine proteases that reverse the ubiquitination by
removing ubiquitins from the target protein. The human genome encodes∼ 100 potential …

Abstract Type I IFN (IFN‐I) is the body's first line of defense against pathogen infection. IFN‐I
can induce cellular antiviral responses and therefore plays a key role in driving antiviral …

STAT1 is a critical transcription factor for regulating host antiviral defenses. STAT1 activation
is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1) …

Summary Type‐I interferons (IFN‐I) are used as common antiviral drugs for a range of viral
diseases in clinic. However, the antiviral efficacy of IFN‐I is largely restricted by negative …

Ubiquitination and deubiquitination have emerged as critical regulatory processes in the
virus-triggered type I interferon (IFN) induction pathway. In this study, we carried out a …

Abstract Type I/III IFNs induce expression of hundreds of IFN-stimulated genes through the
JAK/STAT pathway to combat viral infections. Although JAK/STAT signaling is seemingly …

Viral infectious diseases pose a great challenge to human health around the world. Type I
interferons (IFN-Is) function as the first line of host defense and thus play critical roles during …

The innate immune responses are tightly regulated to ensure effective clearance of invading
pathogens and avoid excessive inflammation. Ubiquitination and deubiquitination are …

Viral infection initiates a series of signaling cascades that activate the transcription factors
nuclear factor kappa B and interferon regulatory factor 3, which collaborate to induce …