Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made
in the elucidation of the pathogenesis of its protean complications, which has inspired recent …

Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin, which has
the unique property of polymerizing when deoxygenated. The pathophysiology of acute and …

Sickle cell anaemia (SCA) is the consequence of abnormal haemoglobin production due to
an inherited point mutation in the β‐globin gene. The resulting haemoglobin tetramer is …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Sickle cell disease has been very well characterized as a single amino acid molecular
disorder of hemoglobin leading to its pathological polymerization, with resulting red cell …

Chronic hemolysis, enhanced oxidative stress, and decreased nitric oxide (NO)
bioavailability promote vasculopathy in sickle cell anemia (SCA). Oxidative stress and NO …

The classical view of sickle cell anemia has always focused on the primary genetic defect—
the abnormal sickle hemoglobin that polymerizes when deoxygenated. Polymerization …

Sickle cell disease (SCD) is characterized by a point mutation that replaces adenine with
thymidine in the sixth codon of the β-globin gene, a unique morphological abnormality of red …