To measure molecular changes underlying pathogen adaptation, we generated a
searchable dataset of more than 12,000 mass spectrometry events, corresponding to lipids …

The prolonged survival of Mycobacterium tuberculosis (M. tb) in the host fundamentally
depends on scavenging essential nutrients from host sources. M. tb scavenges non-heme …

Mycobactins are a family of membrane-associated siderophores required for Mycobacterium
tuberculosis to adapt to its intracellular habitat. These lipophilic siderophores have been …

The mycobactin siderophore system is present in many Mycobacterium species, including
M. tuberculosis and other clinically relevant mycobacteria. This siderophore system is …

Mycobacterium marinum is a model organism for pathogenic Mycobacterium species,
including Mycobacterium tuberculosis, the causative agent of tuberculosis. These pathogens …

Background. Low iron availability in the host upregulates the mbt gene cluster of
Mycobacterium tuberculosis, which is responsible for mycobactin biosynthesis. However, the …

Iron is essential for growth of Mycobacterium tuberculosis, the causative agent of
tuberculosis. To acquire iron from the host, M. tuberculosis uses the siderophores called …

Background: Many pathogenic bacteria secrete iron-chelating siderophores as virulence
factors in the iron-limiting environments of their vertebrate hosts to compete for ferric iron …

Introduction Several decades of antitubercular drug discovery efforts have focused on novel
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …

Iron-starved Mycobacterium tuberculosis utilises the carboxymycobactin-mycobactin
siderophore machinery to acquire iron. These two siderophores have high affinity for ferric …