Parkinson's disease (PD) is a multifactorial disorder involving both motor and non-motor
symptoms caused by the progressive death of distinct neuronal populations, including …

A pathological hallmark of the neurodegenerative disorder, Parkinson's disease (PD), is
aggregation of toxic forms of the presynaptic protein, α‐synuclein in structures known as …

Parkinson's disease (PD) is a neurodegenerative disorder resulting from degeneration of
dopaminergic neurons in the substantia nigra pars compacta (SNpc). PD is characterized by …

The aberrant aggregation of the protein α-synuclein is thought to be involved in Parkinson's
disease (PD). However, the factors that lead to initiation and propagation of α-synuclein …

Parkinson's disease (PD) is a debilitating neurodegenerative condition associated with
tremor, rigidity, dementia, and gastrointestinal symptoms such as constipation, nausea and …

Abstract Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD)
originates in the enteric nervous system (ENS) and spreads to the brain through the vagus …

Parkinson's disease is the second most prevalent neurological disease after Alzheimer's.
Primarily, old age males are more affected than females. The aggregates of oligomeric forms …

Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could
spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α …

Parkinson's disease (PD) is a highly heterogeneous disorder, which probably consists of
multiple subtypes. Aggregation of misfolded alpha-synuclein and propagation of these …

Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons in
the midbrain and the pathological accumulation of misfolded α-synuclein (α-syn) in the …