Since its introduction in the late 19th century, the Langendorff isolated heart perfusion
apparatus, and the subsequent development of the working heart model, have been …

Isolated working heart models have been used to understand the effects of loading
conditions, heart rate and medications on myocardial performance in ways that cannot be …

Traditional working heart preparations, based on the original Langendorff setup, are widely
used experimental models that have tremendously advanced the cardiovascular field …

Background The Langendorff-perfused ex-vivo isolated heart model has been extensively
used to study cardiac function for many years. However, electrical and mechanical function …

Abstract The Langendorff Perfused Heart Model is an experimental procedure developed at
the end of the nineteenth century by Oskar Langendorff. In this procedure, an excised heart …

The Langendorff mouse heart model is widely employed in studies of myocardial function
and responses to injury (eg ischaemia). Nonetheless, marked variability exists in its …

Despite minimal model characterisation Langendorff perfused murine hearts are
increasingly employed in cardiovascular research, and particularly in studies of myocardial …

Oscar Langendorff introduced the first method for isolating a heart with contractile activity in
1895. Since then, the Langendorff method has remained a powerful technique in cardiac …

Background Existing large-animal, ex vivo, cardiac perfusion models are restricted in their
ability to establish an ischemia/reperfusion condition as seen in cardiac surgery or …

Our aim was to develop a working isolated murine heart model, as the extensive use of
genetically engineered mice in cardiovascular research requires development of new …