The structural basis of G-protein-coupled receptor function and dysfunction in human diseases

T Schöneberg, A Schulz, T Gudermann - Reviews of physiology …, 2007 - Springer
Among the different families of transmembrane receptors, G-proteincoupled receptors
(GPCR) form the largest superfamily being present in yeast, plants, protozoa and metazoa …

G protein-coupled receptors: what a difference a 'partner'makes

BT Roux, GS Cottrell - International Journal of Molecular Sciences, 2014 - mdpi.com
G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in
essential physiological processes. GPCRs respond to a wide variety of ligands from light to …

Genetic variation in G-protein-coupled receptors–consequences for G-protein-coupled receptors as drug targets

CM Tang, PA Insel - Expert opinion on therapeutic targets, 2005 - Taylor & Francis
G-protein-coupled receptors (GPCRs), including 'orphan'GPCRs whose natural ligands are
unknown, comprise the largest membrane receptor superfamily and are the most commonly …

[HTML][HTML] Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets

PA Insel, CM Tang, I Hahntow, MC Michel - Biochimica et Biophysica Acta …, 2007 - Elsevier
By virtue of their large number, widespread distribution and important roles in cell
physiology and biochemistry, G-protein-coupled receptors (GPCR) play multiple important …

Mutant G-protein-coupled receptors as a cause of human diseases

T Schöneberg, A Schulz, H Biebermann… - Pharmacology & …, 2004 - Elsevier
G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

GPCR: G protein complexes—the fundamental signaling assembly

B Jastrzebska - Amino acids, 2013 - Springer
G protein coupled receptors (GPCR) constitute the largest group of cell surface receptors
that transmit various signals across biological membranes through the binding and …

[图书][B] G protein-coupled receptors: Molecular pharmacology

G Vauquelin, B Von Mentzer - 2008 - books.google.com
G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of
extracellular signals into intracellular reactions ranging from cell-cell communication …

[HTML][HTML] How genetic errors in GPCRs affect their function: possible therapeutic strategies

H Stoy, VV Gurevich - Genes & diseases, 2015 - Elsevier
Activating and inactivating mutations in numerous human G protein-coupled receptors
(GPCRs) are associated with a wide range of disease phenotypes. Here we use several …

Pharmacogenomic and structural analysis of constitutive G protein–coupled receptor activity

MJ Smit, HF Vischer, RA Bakker… - Annu. Rev …, 2007 - annualreviews.org
G protein–coupled receptors (GPCRs) respond to a chemically diverse plethora of signal
transduction molecules. The notion that GPCRs also signal without an external chemical …

G-protein-coupled receptors and signaling networks: emerging paradigms

MJ Marinissen, JS Gutkind - Trends in pharmacological sciences, 2001 - cell.com
G-protein-coupled receptors (GPCRs) constitute the largest family of cell-surface molecules
involved in signal transmission. These receptors play key physiological roles and their …